by | Mar 2, 2021 | COVID-19 | 23 comments


Long COVID patients are coming out of the woodwork. Many have been desperately seeking answers for months.

Symptoms are frequently severe, debilitating, life changing. And it’s not the elderly. This is the spring break crowd.

Thankfully there is hope:

Doctors around the world are reporting 90%+ success rates with various experimental regimens utilizing cheap generic drugs like ivermectin, steroids and fluvoxamine, but sometimes it’s difficult to predict who will respond to what. And oftentimes the symptoms disappear with treatment only to resurface weeks later.

Tech to the rescue:

Utilizing cutting edge AI and machine learning there are advanced diagnostic tests on the horizon that promise to help determine both optimal therapies and duration of treatment. These include an advanced blood panel and whole body nuclear imaging.

Doesn’t sound cheap, does it?

But not to worry: where there’s a will there’s a way out.


In early 2021 we started seeing a trickle of patients who had spent months and in some cases nearly a year suffering from strange and often debilitating symptoms.

Many had been to multiple specialists and had million dollar workups, including Chest CT scans, Brain MRI’s, exercise stress tests, pulmonary function tests, echocardiograms, doppler ultrasounds, scores of blood tests, allergy testing, and on and on.

They had seen specialists ranging from cardiologists to neurologists, pulmonologists to rheumatologists, endocrinologists to gastroenterologists and all had come up empty, in many cases finally telling them that it was just all in their heads – the usual fall back when every test comes back negative and the syndrome hasn’t been seen before.

Eventually these patients had come to the suspicion that their symptoms might in some way be related to an earlier COVID-19 infection.

Through the power of social networking hashtags like #LongHaulers and #LongCOVID, Facebook groups like the 100k+ member Survivor Corps, online forums like r/covidlonghaulers on Reddit, and even a 14k+ strong Slack group called the Body Politic COVID-19 Support Group, they had discovered others suffering from similar symptoms.

This trickle of patients has been picking up, and I’m worried the long haul problem will prove to be worse than the acute illness itself for the vast majority of affected patients.

And there may be severe long term effects we have yet to discover.

Already there are some indications that severe long term damage has occurred in many who have supposedly recovered. There has been a documented drop of 8 IQ points in the most severe hospitalized patients. Brain fog is a common complaint.

Chronic fatigue is frequent. Many healthy active patients are now wiped out after a few hours of their usual work routine.

Anxiety like symptoms are common. Patients complain of their heart rate suddenly skyrocketing with no warning.

Trouble sleeping is nearly universal. Either unable to get to sleep or stay asleep or both.

Some have terrible body pain or severe daily headaches.

The list goes on and unlike the mortality numbers it is not so much the very elderly who are suffering, it is preteens up through the middle aged that are hit the hardest – at least in terms of who is showing up.

The elderly may be utterly debilitated and disconnected from the social media lifelines that have pulled many younger patients out of confusion and toward some hope. Also many of the elderly have likely gone from independence to nursing home residence.

This is not uncommon after any severe illness requiring lengthy hospitalization in older age groups, but the severity of chronic illness showing up in the young is unprecedented.


The top reported symptoms include:
  • Anxiety and depression
  • arthralgia (joint pain) and myalgia (muscle pain)
  • chest pain, pressure or tightness similar to asthma
  • chills and/or sweats often at night
  • confusion or brain fog, concentration trouble, memory lapses
  • cough usually dry, sometimes slightly productive, usually clear phlegm
  • diarrhea and or constipation sometimes alternating
  • difficulty breathing and shortness of breath, without low oxygen levels
  • fatigue, constant or intermittent, often severe after exercise
  • high or low grade fevers without evidence of infections
  • hair loss
  • headache
  • insomnia
  • lightheadedness and dizziness
  • palpitations (e.g. skipped heart beats) and racing heart
Beyond these there are dozens of other symptoms seen across the spectrum of this illness.


In most patients long haul syndrome seems to be a form of chronic fatigue syndrome (CFS) also known as myalgic encephalitis, which is poorly understood but likely caused by changes in immune system function, a dysfunctional stress response and damage to various mechanisms of mitochondrial energy production.

CFS is sometimes seen in families as is long COVID, so likely has a genetic predisposition that is as yet uncharacterized, meaning we can’t yet predict who will develop it.

Ongoing Chronic Inflammation

The root cause of all chronic disease is some form of chronic inflammation. The inflammatory response in acute COVID-19 infection is so hyperactive that even normally benign and healthy forms of inflammation like exercise can set it off and lead to out of control inflammation that doesn’t stop.

Widespread Microscopic Blood Clotting

This can occur in any organ and leads to diminished function and various organ specific symptoms – when it’s the lungs we see cough, shortness of breath and chest tightness, in the heart the worst case scenario is obstruction of the coronary arteries, in rare cases even young patients with no history of heart disease or any risk factors for it have developed sudden heart attacks precipitated by exercise, in the brain it can manifest as depression, anxiety, brain fog and a host of other symptoms, since after all the brain controls the rest of the body.

Sequestration Within the Brain

There is evidence SARS-COV-2 can enter the brain through the nasal passages and remain after resolution of the acute illness. Since the brain to some extent affects the functioning of every organ, inflammation and dysfunction within the brain could be the root cause of many widespread symptoms.


The general approach should be to first assess if there is one or more particular therapies that are most likely to work based on the presumed source of symptoms, then eliminate any that are contraindicated for any reason, narrow it down to those least likely to cause side effects and if price sensitive start with what is most economical.

In my experience combining too many treatments together is not as effective as choosing the most likely to work and be tolerable and using that on its own. Every intervention sends the body a message and it is possible to send mixed signals and not get anywhere despite choosing therapeutics that work like a charm when used separately.

Common Therapeutic Options

1. Ivermectin 200 – 400mcg/kg for at least 2 days, depending on severity, and if not resolved the treatment is continued until resolution.

Ivermectin was studied for long haul COVID in a small Peruvian study which reported complete resolution in 88% of patients within 2 days and up to 95% resolution with extended dosing beyond 2 days. #LongCOVID #Ivermectin #DrSyedHaider Click To Tweet

In my experience the partial responders and non-responders at 2 days reach complete resolution within a month.

Generally very cheap, safe and well-tolerated with very low incidence of mostly mild side effects. Thought to work primarily due to its anti-inflammatory effects.

2. Dexamethasone 0.5 mg three times a day for 2 days then two times a day for 2 days then once a day for 2 days (can also substitute other low dose steroids if need be like prednisone 5mg).

Reported by Dr. Mobeen Syed (better known to some as “Dr. Been”), a prolific medical educator and Youtube personality who primarily reported using it as a preventive in the second week of acute infection, but found it can also resolve long haul COVID symptoms.

It works by suppressing the overactive immune system and calms inflammation.

The drawback is there are no studies of this protocol, but it is cheap, safe and well-tolerated by most patients. 

3. Fluvoxamine 50mg once or twice a day for 14 days – especially useful for brain fog and other neurological symptoms as it crosses the blood brain barrier and has a therapeutic effect in the brain.

Fluvoxamine benefits in long haul COVID were reported by a few people, most famously Dr. Drew, who was 80% better in hours and 100% better within 2 weeks. It has been shown to be 100% effective in RCTs at preventing long haul syndrome when started during the acute illness.

Fluvoxamine can be combined with mirtazapine 15 mg at night to increase efficacy and decrease side effects.

Fluvoxamine is cheap, safe, with a long history of use for OCD, anxiety and depression. More likely to cause side effects than the first two options.

It has powerful anti-inflammatory effects generated by its activation of the Sigma 1 receptor.

However it may not be an option for those already on another drug in the same class, i.e. the selective serotonin reuptake inhibitors (SSRIs), due to the increased possibility of adverse effects.

4. Colchicine 0.6 mg one to three times a day for 14 – 60 days depending on how far into symptoms.

Championed by Dr. Darrell Dimello, who has treated over 20,000 patients across India, it has been extensively used abroad for preventing and treating long Haul syndrome.

Not so cheap, but still relatively economical and easily within reach for most (with free goodrx coupons the first 3 options are generally 10’s of dollars, but colchicine is low hundreds).

More likely to cause intolerable side effects like severe nausea, vomiting and diarrhea.

The therapeutic effect here is likely based on its powerful anti-inflammatory action.

Alternative: over the counter non-steroidal anti-inflammatories (NSAIDS), especially naproxen 220 – 550 mg every 12 hours. This alone resolved long haul symptoms completely within 48 hours for one of my patients – and it wasn’t my prescription, so kudos to him for figuring it out – hopefully the information will be of benefit to others.

5. Blood thinners – aspirin, plavix, eliquis, lovenox etc.

These have been used by Dr. Dimello and others around the world, often in combination with colchicine or other anti-inflammatories.

Cheap and safe if there is no history of bleeding, stomach ulcers, varices (enlarged blood vessels in the stomach or esophagus that are prone to bleeding) or liver failure. Side effects are generally not a major issue, though some may experience significant bruising.

These presumably work primarily by reversing the microscopic clotting that is brought on by inflammation. Occasionally it’s necessary to do imaging tests like a CT scan to help determine if the stronger ones like injection lovenox are likely to help.

5. Maraviroc

An HIV drug, this is expensive (in the $1000s), and is more risky, with serious and severe side effects sometimes reported.

It works as an anti-inflammatory and balances the immune system. Given the price, side effect profile and various contraindications, it is lower down on the list of options and is unlikely to be necessary for most patients.

6. HCQ and all the rest

There are many other promising drugs, supplements and herbs being used including hydroxychloroquine (cheap and safe despite the media furor) and eventually we hope to be able to refine treatment protocols in order to better predict who will benefit from which medication.

7. Lifestyle

Many patients report cleaning up their diet and lifestyle can partially or completely resolve long haul symptoms

The one tricky aspect is that although exercise is generally part of a healthy lifestyle it often worsens symptoms or brings on exacerbations in long COVID and is commonly the precipitating factor in the initial development of long COVID symptoms – this is similar to chronic fatigue syndrome where it is known that patients have an abnormal and harmful biochemical and metabolic response to exercise.

Because of this most physicians advise patients not exercise until symptoms have fully resolved.

Aside from avoiding exercise, the general approach to a healthy lifestyle is common to any chronic illness and has been laid out in my post A Template for Optimal Health.


The promise of diagnostic tests is that not only will we have verifiable evidence confirming the diagnosis, but we can track changes during treatment and in cases where symptoms disappear and the testing still shows abnormalities, with a trend towards improvement, we might choose to continue therapy until the underlying abnormalities completely resolve in the hopes of curing the illness and thereby preventing recurrences.


This is Dr. Bruce Patterson’s startup. Dr. Patterson is a giant in the field of HIV research and the long haul community is lucky to have him investigating this syndrome.

IncellDx used machine learning to find a specific long COVID diagnostic signature based on characteristic changes in various inflammatory markers and in numbers of various immune system cells in patients with long COVID.

More than 2500 patients and many physicians, including myself have signed up in anticipation of the imminent release of this test.

The Fleming Method

Dr. Richard Fleming is the original proponent of the now mainstream inflammatory model of cardiovascular disease pathogenesis.

His proprietary methodology utilizes quantitative nuclear isotope imaging to detect inflammation indicating active long haul disease.

This is not yet widely available and access depends on finding a nuclear imaging center where staff have been trained and licensed by Dr. Fleming.


Most patients just need to find a doctor willing to work with them until they find a cheap therapy that gets them back to healthy.

Since we are all in uncharted waters this usually requires flexibility and experimentation on the part of both physician and patient.

A readiness to experiment with dosing and frequency, duration and tapering are mandatory for the best results.

Patients need some autonomy within a loose framework so they can adjust treatment at home and frequent follow-up is required.

For those who have the resources diagnostic testing may help provide a shortcut and some much needed empirical validation and it is a last resort in the hypothetical case where everything we can think of may have failed.

But in my experience failures are the exception rather than the rule in long COVID care.

And overall there are many bright rays of hope on the horizon for the long suffering long haulers out there.

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Ryota Katoh
Ryota Katoh
1 year ago

Sir, Dr. Syed Haider

Hello, I am 52 years, male, living in Tokyo Japan.
I was caught by Covid19 January 2021.
After that I have been suffered from LongCovid even now.
Everyday I feel headache, a slight of fever, heavy pain around back of neck, dizziness, lightheadedness, dysgeusia and smell disorder.
These have begun the end of February 2021.

In Japan, although I consult doctors, I cannot obtain effective medicines, therefore I am at a loss what to do(and to whom).

If you know any effective means and medicines, please kindly inform me.

And about Iverrmeccine, I would like to know its effect. We cannot obtain it in Japan on a daily basis.

Sincerely Yours,

Dr Syed Haider
Dr Syed Haider
11 months ago
Reply to  Ryota Katoh

Sorry for the late reply and sorry to hear you have been suffering from Long COVID. There are a number of approaches to long covid, including a fasting protocol by Tom Bunker which triggers autophagy, which is the bodies process for clearing out junk that needs to go (like the spike protein that triggers the problem). He has a facebook group you can joint, but basically he recommends intermittent fasting daily for say 18 hours, and then a longer 48 hours water fast once a week.

If you cannot get access to medications you can also try these supplements:

Life Extension Autophagy Renew x 2 weeks
Life Extension Cytokine Suppress x 2-4 weeks

Also the adage time heals all wounds applies here as well. It seems the majority of people gradually improve over time until they get back to normal eventually.

Anita weeks
Anita weeks
1 year ago

Aloha from Hawaii I have had long COVID for a year now and it’s been a struggle to cope, learn, and and find help . I am grateful that this condition is being recognized now and studies are being done. I have just gotten ivermectin mailed to after much difficulty. I did take 2 doses of the horse paste last week according to my weight . I have a question my pills are 12mg and the dose suggested appears much higher so it’s a little confusing however I am going to take one 12mg a day and see . I have been experiencing low blood pressure however and that concerns me as I become lightheaded. I welcome any information about dosing or anything else helpful I was active so trying to exercise and having it backfire on me with worsening my symptoms makes me lay around too much. Also I have a high quality infrared sauna is it a good thing to use for this condition?

Dr Syed Haider
Dr Syed Haider
11 months ago
Reply to  Anita weeks

Aloha the ivermectin dose depends on weight, there are different protocols being implemented for long covid ranging from 0.1mg/kg every 72 hours up to 0.4mg/kg daily.

Low blood pressure can be a side effect of ivermectin and also fluvoxamine, so those who already have low blood pressure have to be careful.

I don’t know if infrared saunas are helpful in general, though a few patients have reported using them with some success, would be worth a try to see. Let me know if you do give it a go.

11 months ago

Thank you for these comprehensive articles on the evolving state of the art of Covid care. I know they took hours of devoted attention and discipline. Innovation always comes from the grass roots when doctors are free to collaborate and practice their art of medicine.

Americans are fortunate that this care is available even if it is complicated to execute in the current environment.

Dr Syed Haider
Dr Syed Haider
11 months ago
Reply to  Catherine

My pleasure, I only wish I had more time to research and write! Hopefully the word gets out and the protocols spread to more people.

Mariam Kromm
Mariam Kromm
11 months ago

I came across VineHealth Center(vinehealthcenter. com) and their treatment for Coronary Artery Disease, the herbal protocol is a miracle. My artery is clear and I lost some weight too

Dr Syed Haider
Dr Syed Haider
11 months ago
Reply to  Mariam Kromm

Thanks for the heads up, I’ll check it out.

Kate MacIsaac, MD
Kate MacIsaac, MD
11 months ago

Hello, Dr. Haider, I am a physician in FLorida, trying to provide FLCCC prevention and treatment in my patients. I wonder if there are any papers referencing fluvoxamine use in long haul Covid? I have heard you speak several times about using it, but I have patients asking for references, and I have not found any specific papers. Can you help me out? Thank you for all you are doing!

Dr Syed Haider
Dr Syed Haider
11 months ago

There are a few studies on fluvoxamine, you can find the data and references at skirsch.io.

Dennis Ketchum
Dennis Ketchum
11 months ago

Had contacted Dr Haider because of long haul covid symptoms, which were quite disabling.
My Drs would not prescribe any of the helpful medications for me, so I chose to contact Dr Haider‘s clinic. After receiving the treatments, I am so much better. I am able to exercise ( which left me breathless & without energy after having ˋrecovered´ from covid) and can continue with my daily chores afterwards. It is really quite incomprehensible to me, why my Drs claim, there is no proof, no info, no studies on certain meds to help with this virus, etc, when I am able to find the info on the internet ?!?
Would definitely recommend this Dr to you, if you suffer w/ covid related issues! The blogs & info on this website are also really helpful.
Again, so very thankful to have found this provider.
THANK YOU, Dr Haider

David Hunt
David Hunt
10 months ago

Hi Dr Haider, you web site shows closed to new long haul patients, how long term is this and can you refer me to someone else, you know can do a good job? I’m in Michigan.


Dr Syed Haider
Dr Syed Haider
10 months ago
Reply to  David Hunt

I’m currently on prescribing to patients in case they get Long COVID since I am no longer able to personally review the symptoms of the patients that are coming in. You can check with incelldx at covidlonghaulers.com, they should have a list of doctors they refer their long COVID patients to.

10 months ago

Dear Dr Haider,

I lived in Germany. I had 1st dose of Mordena vaccine and few days later sufferred from symptoms like long covid. I have heart palpitation, severe insomnia, anxiety, body tremors, weakness on my left arm, where I had the vaccine , fatigue, pin and needle in various part of my body, muscle twitching. I am not sure if i can use the protocol of long hauler to treat my symptoms. My doctor think I have anxiety and gave me sleeping pills which does not help.

I hope you can give me some advice.

Thank you so much

10 months ago
Reply to  Erin

Sorry i forgot to mention that I am 37 female. I was healthy, happy, optimistic and active before the vaccine. I never experience any of these symptoms before.

Dr Syed Haider
Dr Syed Haider
10 months ago
Reply to  Erin

The only patients I’ve found who cannot take ivermectin are those that are pregnant. Neurological symptoms often benefit from fluvoxamine or fluoxetine, which are drugs commonly used in anxiety anyway, so not usually that hard to get prescribed from a regular doctor, even one that is not on board with off-label prescribing for COVID-19.

Fasting can help as well, See Tom Bunker’s facebook group where you can request his fasting protocol. And finally time heals all wounds, and seems to work for vaccine side effects as well as long COVID.

Melinda Gutman
Melinda Gutman
9 months ago

Dr Haider,
Thank you for the work you are doing to help people suffering with Long Covid. I had Covid in March 2020. I was prescribed HCG as well as azithromycin. I recovered after 3 weeks. Four months later, I started having pain in my right heel, like I was stepping on a rock. A Podiatrist decided I had Planters. I knew I didn’t. My foot hurt with use, not when I first got up in the morning. I saw a Physical Therapist, who thought I had Tarsal Tunnel. After months of therapy, the pain was getting worse, and had spread into my other foot and both wrists. I’ve had times that just having a little breeze touch my feet was excruciating. Sometimes it feels like bees are stinging my toes. At times, the pain has been so bad, I wanted to just cut them off. I’ve had bloodwork, MRI’s, and a nerve conduction study. Everything has come back normal.

I’ve received pressure from doctors to get the vaccine because it is helping some people with long Covid. But I’ve seen so many reports of people experiencing neuropathy after the vaccine, that I’m afraid to risk making my situation worse by getting it.

My doctor prescribed Ivermectin several months ago, but it didn’t help. I have increased my intake of Zinc, and am taking additional supplements for my immune system, such as Quercetin. My doctor prescribed HCQ for me to try, I started taking it yesterday.

Is there a particular protocol that seems to help with neuropathy caused by having had Covid? I appreciate any advice you can give.

8 months ago

I met covid in Aug of 21… I was on the roller coaster for 10 days and could tell that I was going to be in the long hauler covid if I did not seek help. My Dr. in the corporate health care industry was useless… I found The Johnson Medical Group and they are the ones that helped me acquire 3 meds..
1 Budesonide
2 Hydroxycloriquine
3 doxycycolene
**excuse the spelling
Total cost was less than $50… filled scripts at Walgreens… took the first dose of each. went to bed and woke to feel about 80% better… next day full 2 doses. Woke up day three feeling like I was 10 years younger. Continued taking the meds for a month and found a Doc that is not part of the Medical Industrial Complex. He knocked it out completely with a steroid (I’m sorry i can’t recall the name) I now feel pretty darn good. I can run 3 miles but from time to time while just relaxing I have noticed a shortness of breath. I’m not worried but something I will bring up when I see my Dr. (with some balls to do the right thing) on my next visit. BTW he has treated 10 of my friends that were in early covid with the same meds and they sailed through it by the next day.

People think I’m crazy when I tell my story. So many have been told there are no treatments.

THERE IS NO REASON TO SUFFER… don’t be a tough guy. I wish I had sought help sooner.

Thank You for this website and the opportunity to share my story.

Dave D.

Lori Deis
Lori Deis
7 months ago

I got the shedding from giving my neighbors a ride they both took the pfizer shots 1 and 2 , I have massive headaches, bleeding , numbness and tangleing in my toes and fingers, my back feels like it is fire, bruising all over my legs, it feels like I am dying , my period is never the same , one month I had 2 periods, and last month I had no period, I feel tired and thristy all of the time, this as been going on since 6/24/2021 and I really need advice Thanks so much

Linda Evans
Linda Evans
6 months ago

I have been suffering from LongCovid for two months after contracting Delta…started feeling a little better after a week of Ivermectin twice a day. Then caught Omicron, and now feeling bad again. Am seeing a holistic doctor today to try and get some help. I wake at night after a short time and my body is trembling and my heart is beating fast. It seems after I get in to a deep sleep, is when it happens. This happens several times a nite and its wearing me out. I dont like to go to bed anymore so sleep in the recliner in the family room. I am anxious all the time ….but really bad anxiety after I have a waking up from deep sleep with heart pounding. I am at a loss for what to do for help. I have been to the ER three times and of course they have no idea what’s going on. Thats the bad part…there is not much help out there..hopefully this will be more fully researched in the near future…

2 months ago
Reply to  Linda Evans

Hello, Ms. Evans,

We apologize for the late reply. We will do our best to monitor these comments and reply to them in a timely manner.

I want to invite you to sign up as a patient and fill out a complete health questionnaire at the link below so Dr. Haider can evaluate your current medical problems and symptoms and give you his best recommendations. If you aren’t aware, Dr. Haider has been treating acute COVID patients for over a year now and is one of the very few doctors out there who specializes in the treatment of Long Haul COVID.

Please register here: https://mygotodoc.com/get-rx

I’m sure you have many questions for him, so I recommend scheduling a visit. In any case, please register to get access to unlimited asynchronous text chat with or without a prescription. This is a free service we offer to all patients.

If you need further assistance, please feel free to chat with our Patient Support Squad through the chat widget on our website or give us a call at 281-219-7367.

Sheryl E.
Patient Support Squad

5 months ago

My daughter had covid last year and doesn’t have any symptoms except her taste has not come back to normal. It’s not completely gone but things like chocolate tastes weird to her.

2 months ago
Reply to  Kirk

Hello Kirk,

Is your daughter over 18 years of age? If so, I want to invite her to sign up as a patient and fill out a complete health questionnaire at the link below so Dr. Haider can evaluate her current medical problems and symptoms and give his best recommendations. You’re welcome to sign up as a patient also, and then you can add her to your patient portal as a family member if she’s under 18.

Please register here: https://mygotodoc.com/get-rx

One-on-one consultation with Dr. Haider is available!

If you need further assistance, please feel free to chat with our Patient Support Squad through the chat widget on our website or give us a call at 281-219-7367.

Sheryl E.
Patient Support Squad